Laboratory interference in the thyroid function test

Interference in laboratory tests

Interference in clinical laboratory testing can create discrepancies in test results which can lead to patient harm.  In clinical chemistry, interference is defined as a cause of medically significant difference in the measurand test result due to another component or property of the sample. Interference by endogenous and exogenous substances with assays for clinical analytes is a common prob...

Relationship between Anti-Thyroid Peroxidase Antibody and Thyroid Function Test

Background: Anti-thyroid peroxidase antibody (anti-TPO antibody) is a member of thyroid autoantibodies which are important in inducing and also diagnosing autoimmune thyroid diseases. Thyroid autoimmunity can cause several forms of thyroiditis and abnormal thyroid functions, ranging from hypothyroidism to hyperthyroidism. Objective: To evaluate the relationship between serum levels of anti-TPO ...

Laboratory evaluation of thyroid function.

The laboratory assessment of thyroid function. Nomenclature.

It is clearly desirable that there should be an agreed standard nomenclature for thyroid function tests, and an agreed method of reporting them. A working party of the American Thyroid Association has proposed a 'Nomenclature for tests of thyroid hormones in serum' which was approved by that Association for publication (Solomon, Benotti, De Groot, Greer, Pilleggi, Pittman, Robbens, Selenkow, St...

Immunoradiometric assay of thyrotropin as a "first-line" thyroid-function test in the routine laboratory.

We compared the utility of a sensitive immunoradiometric assay for serum thyrotropin as a "first-line" thyroid-function test with a strategy based on first measuring total thyroxin in serum. The immunoradiometric assay appears to distinguish primary hypothyroidism and hyperthyroidism from euthyroidism in "new" patients. The role of this test in monitoring antithyroid treatment or thyroxin-repla...